During this time over 1 000 articles have been published in the field, making a full comprehensive review citing all papers impossible. As a result, we seek to highlight the papers we find to be most impactful for the field. We also limited our search criteria and resulting discussion to papers describing analytical measurements. In recent years, paper as a substrate material has been used more frequently for electronics as evidenced by a number of excellent reviews. While many of these reports have bearing and importance to analytical measurements, they are not discussed here in interest of maintaining focus. The same is true of lateral flow immunoassays. Lateral flow immunoassays warrant a separate review based on their ubiquity and have been covered recently. Finally, searches were done using a combination of Google Scholar, Web of Science, PubMed, and SciFinder. In addition, high impact journals were scanned for manuscripts that did not readily appear with standard search terms. Despite these extensive searches, we have, without a doubt, missed many excellent papers relating to paper microfluidics. For those papers missed, we apologize in advance.